MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is a 16-amino acid peptide encoded within the mitochondrial 12S rRNA region, identified as part of a class of mitochondrial-derived peptides. Since its discovery, MOTS-c has been the subject of growing research literature focused on mitochondrial-to-nuclear signaling and metabolic regulation.
In research models, MOTS-c has been studied for its activity in cellular energy metabolism, AMPK signaling pathways, and glucose-related signaling at the cellular level. Investigations have explored its role in mitochondrial homeostasis, folate-methionine cycle interactions, and metabolic stress response pathways in laboratory settings.
MOTS-c has also been examined in research contexts focused on insulin sensitivity markers, exercise-related signaling, and aging-related metabolic pathways. Published studies have characterized its tissue distribution, response to metabolic stressors, and downstream effects on metabolic markers across multiple research designs.
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Product Notes
– Product: MOTS-c (Mitochondrial-Derived Peptide)
– Strength: 10mg, 20mg, or 40mg per vial (select strength)
– Storage: Store lyophilized vial refrigerated; reconstituted vial refrigerated and used within researcher-determined timeframe
– Category: Metabolic / Weight Management
– Intended Positioning: Research Use Only
For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease.





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